Updated May 1, 2019
| AL East | Closer | Job security | Tier | Next up | Wild card |
| Baltimore Orioles | Mychael Givens (committee) | + | 5 | Paul Fry | Miguel Castro |
| Boston Red Sox | Ryan Brasier | + | 5 | Matt Barnes | Tyler Thornburg |
| New York Yankees | Aroldis Chapman | +++ | 1 | Zach Britton | Adam Ottavino |
| Tampa Bay Rays | Jose Alvarado (committe) | ++ | 3 | Diego Castillo | Emilio Pagan |
| Toronto Blue Jays | Ken Giles | ++ | 3 | Joe Biagini | Ryan Tepera |
| AL Central | |||||
| Chicago White Sox | Alex Colome | ++ | 3 | Kelvin Herrera | Nate Jones |
| Cleveland Indians | Brad Hand | +++ | 2 | Adam Cimber | Danny Salazar (inj) |
| Detroit Tigers | Shane Greene | ++ | 3 | Joe Jimenez | Drew VerHagen |
| Kansas City Royals | Ian Kennedy (committee) | + | 5 | Wily Peralta | Brad Boxberger |
| Minnesota Twins | Blake Parker (committee) | + | 5 | Trevor May | Taylor Rodgers |
| AL West | |||||
| Houston Astros | Roberto Osuna | +++ | 1 | Ryan Pressly | Hector Rondon |
| Los Angeles Angels | Hansel Robles (committee) | + | 5 | Ty Buttrey | Cody Allen (inj) |
| Oakland Athletics | Blake Treinen | +++ | 2 | Lou Trivino | Joakim Soria |
| Seattle Mariners | Anthony Swarzak (committee) | + | 5 | Roenis Elias | Hunter Strickland (Inj) |
| Texas Rangers | Jose Leclerc | + | 5 | Shawn Kelley | Jesse Chavez |
| NL East | |||||
| Atlanta Braves | AJ Minter | + | 4 | Luke Jackson | Dan Winkler |
| Miami Marlins | Sergio Romo (committee) | + | 5 | Adam Conley | Tayron Guerrero |
| New York Mets | Edwin Diaz | +++ | 1 | Jeurys Familia | Robert Gsellman |
| Philadelphia Philles | Hector Neris (committee) | ++ | 3 | Seranthony Dominguez | David Robertson (inj) |
| Washington Nationals | Sean Doolittle | +++ | 2 | Kyle Barraclough | Justin Miller |
| NL Central | |||||
| Chicago Cubs | Pedro Strop | + | 3 | Steve Cishek | Brandon Morrow (inj) |
| Cincinnati Reds | Raisel Iglesias | +++ | 3 | Jared Hughes | David Hernandez |
| Milwaukee Brewers | Josh Hader | ++ | 1 | Jeremy Jeffress | Jacob Barnes |
| Pittsburgh Pirates | Felipe Vazquez | +++ | 2 | Keone Kela | Richard Rodriguez |
| St Louis Cardinals | Jordan Hicks | ++ | 2 | Andrew Miller | John Gant |
| NL West | |||||
| Arizona Diamondbacks | Greg Holland | + | 5 | Archie Bradley | Yoshihisa Hirano |
| Colorado Rockies | Wade Davis | +++ | 2 | Scott Oberg | Seunghwan Oh |
| Los Angeles Dodgers | Kenley Jansen | +++ | 1 | Joe Kelly | Pedro Baez |
| San Diego Padres | Kirby Yates | ++ | 2 | Craig Stammen | Phil Maton |
| San Francisco Giants | Will Smith | ++ | 3 | Mark Melancon | Reyes Moranta |